Police and emergency services were called to the scene on Coates Road just before midnight.
Three men were in a car that crashed into a tree near Alexandra Airport. One passenger had moderate injuries and raised the alarm, while two other passengers were initially trapped.
One of the trapped men was taken to Dunedin Hospital via helicopter with serious inuries, while the other man died at the scene.
No other vehicles were involved in the crash and the serious crash unit are investigating.
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