Ten people, including two children, are in hospital after multiple vehicles crashed in Maheno, near Oamaru this evening.
St John ambulance said at least two people were in a critical condition.
The injured children were in a serious condition.
The other people had serious and moderate injuries.
Two people trapped in a car were rescued by fire crews.
Four helicopters and five ambulances took people to Oamaru and Dunedin hospitals.
State Highway 1 is blocked and diversions are in place between Fortification and Happy Valley roads.