The Waikato Westpac Rescue Helicopter was dispatched at 9:30pm to a single car crash on Lake Arapuni road near Waotu.
Five girls were all injured when there vehicle left the road and crashed into the side wall of a farmers concrete underpass.
The 17-year-old driver and a 15-year-old passenger received multiple injuries.
They were both loaded on stretchers and flown together to Waikato Hospital for further assessment and treatment.
The remaining three passengers were taken by road ambulance to Waikato Hospital with minor to moderate injuries.